Publications
A systematic review to compare chemical hazard predictions of the zebrafish embryotoxicity test with mammalian prenatal developmental toxicity
Sebastian Hoffmann, Bianca Marigliani, Sevcan Gül Akgün-Ölmez, Danielle Ireland, Rebecca Cruz, Francois Busquet, Burkhard Flick, Manoj Lalu, Elizabeth C Ghandakly, Rob B M de Vries, Hilda Witters, Robert A Wright, Metin Ölmez, Catherine Willett, Thomas Hartung, Martin L Stephens, Katya Tsaioun. Toxicological Sciences, 09 June 2021
https://doi.org/10.1093/toxsci/kfab072
Applying evidence-based methods to the development and use of adverse outcome pathways
de Vries, R. B. M., Angrish, M., Browne, P., Brozek, J., Rooney, A. A., Wikoff, D. S., Whaley, P., Edwards, S. W., Morgan, R. L., Druwe, I. L., Hoffmann, S., Hartung, T., Thayer, K., Avey, M. T., Beverly, B. E. J., Falavigna, M., Gibbons, C., Goyak, K., Kraft, A., Nampo, F., Qaseem, A., Sears, M., Singh, J. A., Willett, C., Yost, E. Y. ., Schünemann, H. and Tsaioun, K. ALTEX—Alternatives to animal experimentation, 38(2), pp. 336-347.
https://www.altex.org/index.php/altex/article/view/2248
Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review
Hubert Dirven, Gunn E. Vist, Sricharan Bandhakavi, Jyotsna Mehta, Seneca E. Fitch, Pandora Pound, Rebecca Ram, Breanne Kincaid, Cathalijn H. C. Leenaars, Minjun Chen, Robert A. Wright, Katya Tsaioun. Scientific Reports volume 11, Article number: 6403 (2021)
https://doi.org/10.1038/s41598-021-85708-2
Knowledge organization systems for systematic chemical assessments
Paul Whaley, Stephen W. Edwards, Andrew Kraft, Kate Nyhan, Andrew Shapiro, Sean Watford, Steven Wattam, Taylor Wolffe, and Michelle Angrish. Environmental Health Perspectives, Volume 128, No. 12, December 2020.
https://ehp.niehs.nih.gov/doi/full/10.1289/EHP6994
Reviewing the animal literature: how to describe and choose between different types of literature reviews
Cathalign Leenaars, Katya Tsaioun, Frans Stafleu, Kieron Rooney, Franck Meiboom, Merel Ritskes-Hoitinga, Andre Bleich
pubmed.gov, November 2020
https://pubmed.ncbi.nlm.nih.gov/33135562/
Artificial Intelligence for chemical risk assessment
Clemens Wittwehr, Paul Blomstedt, John Paul Gosling, Tomi Peltola, Barbara Raffael, Andrea-Nicole Richarz, Marta Sienkiewicz, Paul Whaley, Andrew Worth, Maurice Whelan. Computational Toxicology, Volume 13, 2020, 100114, ISSN 2468-1113.
https://doi.org/10.1016/j.comtox.2019.100114
A survey of systematic evidence mapping practice and the case for knowledge graphs in environmental health and toxicology
Taylor A M Wolffe, John Vidler, Crispin Halsall, Neil Hunt, Paul Whaley. Toxicological Sciences, Volume 175, Issue 1, May 2020, Pages 35–49,
https://doi.org/10.1093/toxsci/kfaa025
Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER)
Paul Whaley, Elisa Aiassa, Claire Beausoleil, Anna Beronius, Gary Bilotta, Alan Boobis, Rob de Vries, Annika Hanberg, Sebastian Hoffmann, Neil Hunt, Carol F. Kwiatkowski, Juleen Lam, Steven Lipworth, Olwenn Martin, Nicola Randall, Lorenz Rhomberg, Andrew A. Rooney, Holger J. Schünemann, Daniele Wikoff, Taylor Wolffe, Crispin Halsall. Environment International, Volume 143, 2020, 105926, ISSN 0160-4120.
https://doi.org/10.1016/j.envint.2020.105926.
Establishing a health-based recommended occupational exposure limit for nitrous oxide using experimental animal data—A systematic review protocol
Judith A.K.R. van Luijk, Madaline Popa, Janne Swinkels, Julia M.L. Menon, Wynad Alkema, Nel Roeleveld, Sebastian E. Hoffmann, Vivi Schlunssen, Daniele Mandrioli, Merel Ritskes-Hoitinga, Paul T.J. Scheepers. Environmental Research, Volume 178, November 2019, 108711.
https://www.sciencedirect.com/science/article/pii/S0013935119305080
Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management
Taylor A.M. Wolffe, Paul Whaley, Crispin Halsall, Andrew A.Rooney, Vickie R.Walker
Environment International, Volume 130, September 2019, 104871.
https://doi.org/10.1016/j.envint.2019.05.065
Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity Test
Martin L Stephens, Sevcan Gül Akgün-Ölmez, Sebastian Hoffmann, Rob de Vries, Burkhard Flick, Thomas Hartung, Manoj Lalu, Alexandra Maertens, Hilda Witters, Robert Wright, Katya Tsaioun. Toxicological Sciences, June 16, 2019.
https://doi.org/10.1093/toxsci/kfz128
Software tools for literature screening in systematic reviews in biomedical research
Stevie van der Mierden, Katya Tsaioun, André Bleich, Cathalijn H. C. Leenaars (2019). ALTEX—Alternatives to animal experimentation. doi: 10.14573/altex.1902131.
https://www.altex.org/index.php/altex/article/view/1257
Toward Good In Vitro Reporting Standards
Hartung, Thomas, de Vries, Rob, Hoffmann, Sebastian, Hogberg, Helena T., Smirnova, Lena, Tsaioun, Katya, Whaley, Paul Alexander, Leist, Marcel (2019). ALTEX—Alternatives to Animal Experimentation, 36 (1). pp. 3-17. ISSN 1868-8551.
https://doi.org/10.14573/altex.1812191
Evidence integration in risk assessment: the science of combining apples and oranges
European Food Safety Authority
https://doi.org/10.2903/sp.efsa.2018.EN-1396
A primer on systematic reviews in toxicology
Hoffmann, S., de Vries, R.B.M., Stephens, M.L. et al. Arch Toxicol 91, 2551–2575 (2017).
https://doi.org/10.1007/s00204-017-1980-3
The Emergence of Systematic Review in Toxicology
Stephens ML, Betts K, Beck NB, Cogliano V, Dickersin K, Fitzpatrick S, Freeman J, Gray G, Hartung T, McPartland J, Rooney AA, Scherer RW, Verloo D, Hoffmann S. Toxicol Sci. 2016 Jul;152 (1):10-6.
https://doi.org/10.1093/toxsci/kfw059
Evidence-Based Toxicology
Hoffmann S, Hartung T, Stephens M. Adv Exp Med Biol. 2016;856:231-241.
https://link.springer.com/chapter/10.1007%2F978-3-319-33826-2_9
Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review
Samuel GO, Hoffmann S, Wright RA, Lalu MM, Patlewicz G, Becker RA, DeGeorge GL, Fergusson D, Hartung T, Lewis RJ, Stephens ML. Environ Int. 2016 Jul-Aug;92-93:630-46.
doi: 10.1016/j.envint.2016.03.010
Evidence-Based Toxicology
Reference Module in Biomedical Sciences.
Encyclopedia of Toxicology (Third Edition), 2014
Evidence-based toxicology for the 21st century: Opportunities and challenges
Stephens ML, Andersen M, Becker RA, Betts K, Boekelheide K, Carney E, Chapin R, Devlin D, Fitzpatrick S, Fowle JR 3rd, Harlow P, Hartung T, Hoffmann S, Holsapple M, Jacobs A, Judson R, Naidenko O, Pastoor T, Patlewicz G, Rowan A, Scherer R, Shaikh R, Simon T, Wolf D, Zurlo J. ALTEX. 2013;30(1):74-103.
doi: 10.14573/altex.2013.1.074
Food for thought… on evidence-based toxicology
Hartung T. ALTEX. 2009;26(2):75-82.
doi: 10.14573/altex.2009.2.75.
Toward an evidence-based toxicology
Hoffmann S, Hartung T. Hum Exp Toxicol. 2006 Sep;25(9):497-513.
doi: 10.1191/0960327106het648oa.
Diagnosis: toxic!—Trying to apply approaches of clinical diagnostics and prevalence in toxicological considerations
Sebastian Hoffmann, Thomas Hartung. Toxicological Sciences, Volume 85, Issue 1, May 2005, Pages 422–428
https://doi.org/10.1093/toxsci/kfi099