Publications
Probabilistic risk assessment - the keystone for the future of toxicology
Maertens A, Golden E, Luechtefeld TH, Hoffmann S, Tsaioun K, Hartung T. Probabilistic risk assessment - the keystone for the future of toxicology. ALTEX. 2022;39(1):3-29. doi: 10.14573/altex.2201081. PMID: 35034131; PMCID: PMC8906258.
How evidence-based methodologies can help identify and reduce uncertainty in chemical risk assessment
Hoffmann S, Whaley P, Tsaioun K. How evidence-based methodologies can help identify and reduce uncertainty in chemical risk assessment. ALTEX. 2022 Jan 31. doi: 10.14573/altex.2201131. Epub ahead of print. PMID: 35100433.
Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks
Hoffmann S, Aiassa E, Angrish M, Beausoleil C, Bois FY, Ciccolallo L, Craig PS, De Vries RBM, Dorne JLCM, Druwe IL, Edwards SW, Eskes C, Georgiadis M, Hartung T, Kienzler A, Kristjansson EA, Lam J, Martino L, Meek B, Morgan RL, Munoz-Guajardo I, Noyes PD, Parmelli E, Piersma A, Rooney A, Sena E, Sullivan K, Tarazona J, Terron A, Thayer K, Turner J, Verbeek J, Verloo D, Vinken M, Watford S, Whaley P, Wikoff D, Willett K, Tsaioun K. Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. ALTEX. 2022 Mar 1. doi: 10.14573/altex.2202141. Epub ahead of print. PMID: 35258090.
https://www.altex.org/index.php/altex/article/view/2436 Assessing author willingness to enter study information into structured data templates as part of the manuscript submission process: a pilot study
A. Amina Wilkins, Amanda S. Persad, Ingrid L. Druwe, Janice S. Lee, Paul Whaley, Michele M. Taylor, Andrew J. Shapiro, Natalie Blanton, Courtney Lemeris, Kristina A. Thayer,
Assessing author willingness to enter study information into structured data templates as part of the manuscript submission process: a pilot study, Heliyon, 2022, e09095, ISSN 2405-8440,
https://doi.org/10.1016/j.heliyon.2022.e09095.
https://www.sciencedirect.com/science/article/pii/S2405844022003838
Probabilistic risk assessment – the keystone for the future of toxicology
Maertens A, Golden E, Luechtefeld TH, Hoffmann S, Tsaioun K, Hartung T. Probabilistic risk assessment - the keystone for the future of toxicology. ALTEX. 2022;39(1):3-29. doi: 10.14573/altex.2201081. PMID: 35034131; PMCID: PMC8906258.
https://www.altex.org/index.php/altex/article/view/2413 Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do
Whaley P, Blaauboer BJ, Brozek J, Cohen Hubal EA, Hair K, Kacew S, Knudsen TB, Kwiatkowski CF, Mellor DT, Olshan AF, Page MJ, Rooney AA, Radke EG, Shamseer L, Tsaioun K, Tugwell P, Wikoff D, Woodruff TJ.. ALTEX. 2021;38(3):513-522. doi: 10.14573/altex.2106111. Epub 2021 Jun 22. PMID: 34164697.
https://www.altex.org/index.php/altex/article/view/2307
Systematic review in evidence-based risk assessment
Farhat, N., Tsaioun, K., Saunders-Hastings, P., Morgan, R. L., Ramoju, S., Hartung, T. and Krewski, D. (2021) “Systematic review in evidence-based risk assessment”, ALTEX - Alternatives to animal experimentation. doi: 10.14573/altex.2004111.
https://www.altex.org/index.php
A systematic review to compare chemical hazard predictions of the zebrafish embryotoxicity test with mammalian prenatal developmental toxicity
Hoffmann S, Marigliani B, Akgün-Ölmez SG, Ireland D, Cruz R, Busquet F, Flick B, Lalu M, Ghandakly EC, de Vries RBM, Witters H, Wright RA, Ölmez M, Willett C, Hartung T, Stephens ML, Tsaioun K. A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity. Toxicol Sci. 2021 Aug 30;183(1):14-35. doi: 10.1093/toxsci/kfab072. PMID: 34109416; PMCID: PMC8404989.
https://doi.org/10.1093/toxsci/kfab072 Applying evidence-based methods to the development and use of adverse outcome pathways
de Vries, R. B. M., Angrish, M., Browne, P., Brozek, J., Rooney, A. A., Wikoff, D. S., Whaley, P., Edwards, S. W., Morgan, R. L., Druwe, I. L., Hoffmann, S., Hartung, T., Thayer, K., Avey, M. T., Beverly, B. E. J., Falavigna, M., Gibbons, C., Goyak, K., Kraft, A., Nampo, F., Qaseem, A., Sears, M., Singh, J. A., Willett, C., Yost, E. Y. ., Schünemann, H. and Tsaioun, K. ALTEX—Alternatives to animal experimentation, 38(2), pp. 336-347.
https://www.altex.org/index.php/altex/article/view/2248
Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review
Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE, Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. Sci Rep. 2021 Mar 18;11(1):6403. doi: 10.1038/s41598-021-85708-2. PMID: 33737635; PMCID: PMC7973584.
https://doi.org/10.1038/s41598-021-85708-2 Knowledge organization systems for systematic chemical assessments
Whaley P, Edwards SW, Kraft A, Nyhan K, Shapiro A, Watford S, Wattam S, Wolffe T, Angrish M. Knowledge Organization Systems for Systematic Chemical Assessments. Environ Health Perspect. 2020 Dec;128(12):125001. doi: 10.1289/EHP6994. Epub 2020 Dec 24. PMID: 33356525; PMCID: PMC7759237.
https://ehp.niehs.nih.gov/doi/full/10.1289/EHP6994 Reviewing the animal literature: how to describe and choose between different types of literature reviews
Leenaars C, Tsaioun K, Stafleu F, Rooney K, Meijboom F, Ritskes-Hoitinga M, Bleich A. Reviewing the animal literature: how to describe and choose between different types of literature reviews. Lab Anim. 2021 Apr;55(2):129-141. doi: 10.1177/0023677220968599. Epub 2020 Nov 1. PMID: 33135562; PMCID: PMC8044607.
https://pubmed.ncbi.nlm.nih.gov/33135562/ Artificial Intelligence for chemical risk assessment
Wittwehr C, Blomstedt P, Gosling JP, Peltola T, Raffael B, Richarz AN, Sienkiewicz M, Whaley P, Worth A, Whelan M. Artificial Intelligence for chemical risk assessment. Comput Toxicol. 2020 Feb;13:100114. doi: 10.1016/j.comtox.2019.100114. PMID: 32140631; PMCID: PMC7043333.
https://doi.org/10.1016/j.comtox.2019.100114 A survey of systematic evidence mapping practice and the case for knowledge graphs in environmental health and toxicology
Wolffe TAM, Vidler J, Halsall C, Hunt N, Whaley P. A Survey of Systematic Evidence Mapping Practice and the Case for Knowledge Graphs in Environmental Health and Toxicology. Toxicol Sci. 2020 May 1;175(1):35-49. doi: 10.1093/toxsci/kfaa025. PMID: 32096866; PMCID: PMC7261145.
https://doi.org/10.1093/toxsci/kfaa025 Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER)
Whaley P, Aiassa E, Beausoleil C, Beronius A, Bilotta G, Boobis A, de Vries R, Hanberg A, Hoffmann S, Hunt N, Kwiatkowski CF, Lam J, Lipworth S, Martin O, Randall N, Rhomberg L, Rooney AA, Schünemann HJ, Wikoff D, Wolffe T, Halsall C. Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER). Environ Int. 2020 Oct;143:105926. doi: 10.1016/j.envint.2020.105926. Epub 2020 Jul 9. PMID: 32653802.
https://doi.org/10.1016/j.envint.2020.105926. Establishing a health-based recommended occupational exposure limit for nitrous oxide using experimental animal data—A systematic review protocol
van Luijk JAKR, Popa M, Swinkels J, Menon JML, Alkema W, Roeleveld N, Hoffmann SE, Schlünssen V, Mandrioli D, Ritskes-Hoitinga M, Scheepers PTJ. Establishing a health-based recommended occupational exposure limit for nitrous oxide using experimental animal data - A systematic review protocol. Environ Res. 2019 Nov;178:108711. doi: 10.1016/j.envres.2019.108711. Epub 2019 Sep 7. PMID: 31520819.
https://www.sciencedirect.com/science/article/pii/S0013935119305080 Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management
Wolffe TAM, Whaley P, Halsall C, Rooney AA, Walker VR. Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management. Environ Int. 2019 Sep;130:104871. doi: 10.1016/j.envint.2019.05.065. Epub 2019 Jun 26. PMID: 31254867; PMCID: PMC7189619.
Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity Test
Stephens ML, Akgün-Ölmez SG, Hoffmann S, de Vries R, Flick B, Hartung T, Lalu M, Maertens A, Witters H, Wright R, Tsaioun K. Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity Test. Toxicol Sci. 2018 Jun 13;171(1):56–68. doi: 10.1093/toxsci/kfz128. Epub ahead of print. PMID: 31192353; PMCID: PMC6736188.
https://doi.org/10.1093/toxsci/kfz128 Software tools for literature screening in systematic reviews in biomedical research
Van der Mierden S, Tsaioun K, Bleich A, Leenaars CHC. Software tools for literature screening in systematic reviews in biomedical research. ALTEX. 2019;36(3):508-517. doi: 10.14573/altex.1902131. Epub 2019 May 16. PMID: 31113000..
https://www.altex.org/index.php/altex/article/view/1257 Toward Good In Vitro Reporting Standards
Hartung T, De Vries R, Hoffmann S, Hogberg HT, Smirnova L, Tsaioun K, Whaley P, Leist M. Toward Good In Vitro Reporting Standards. ALTEX. 2019;36(1):3-17. doi: 10.14573/altex.1812191. PMID: 30633302.
https://doi.org/10.14573/altex.1812191 Evidence integration in risk assessment: the science of combining apples and oranges
European Food Safety Authority
https://doi.org/10.2903/sp.efsa.2018.EN-1396
A primer on systematic reviews in toxicology
Hoffmann S, de Vries RBM, Stephens ML, Beck NB, Dirven HAAM, Fowle JR 3rd, Goodman JE, Hartung T, Kimber I, Lalu MM, Thayer K, Whaley P, Wikoff D, Tsaioun K. A primer on systematic reviews in toxicology. Arch Toxicol. 2017 Jul;91(7):2551-2575. doi: 10.1007/s00204-017-1980-3. Epub 2017 May 13. PMID: 28501917; PMCID: PMC5489636.
https://doi.org/10.1007/s00204-017-1980-3 The Emergence of Systematic Review in Toxicology
Stephens ML, Betts K, Beck NB, Cogliano V, Dickersin K, Fitzpatrick S, Freeman J, Gray G, Hartung T, McPartland J, Rooney AA, Scherer RW, Verloo D, Hoffmann S. The Emergence of Systematic Review in Toxicology. Toxicol Sci. 2016 Jul;152(1):10-6. doi: 10.1093/toxsci/kfw059. Epub 2016 May 5. PMID: 27208075; PMCID: PMC4922539.
https://doi.org/10.1093/toxsci/kfw059 Evidence-Based Toxicology
Hoffmann S, Hartung T, Stephens M. Evidence-Based Toxicology. Adv Exp Med Biol. 2016;856:231-241. doi: 10.1007/978-3-319-33826-2_9. PMID: 27671725.
https://link.springer.com/chapter/10.1007%2F978-3-319-33826-2_9 Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review
Samuel GO, Hoffmann S, Wright RA, Lalu MM, Patlewicz G, Becker RA, DeGeorge GL, Fergusson D, Hartung T, Lewis RJ, Stephens ML. Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review. Environ Int. 2016 Jul-Aug;92-93:630-46. doi: 10.1016/j.envint.2016.03.010. Epub 2016 Mar 31. PMID: 27039952.
doi: 10.1016/j.envint.2016.03.010 Evidence-Based Toxicology
Reference Module in Biomedical Sciences.
Encyclopedia of Toxicology (Third Edition), 2014
Evidence-based toxicology for the 21st century: Opportunities and challenges
Stephens ML, Andersen M, Becker RA, Betts K, Boekelheide K, Carney E, Chapin R, Devlin D, Fitzpatrick S, Fowle JR 3rd, Harlow P, Hartung T, Hoffmann S, Holsapple M, Jacobs A, Judson R, Naidenko O, Pastoor T, Patlewicz G, Rowan A, Scherer R, Shaikh R, Simon T, Wolf D, Zurlo J. Evidence-based toxicology for the 21st century: opportunities and challenges. ALTEX. 2013;30(1):74-103. doi: 10.14573/altex.2013.1.074. PMID: 23338808.
doi: 10.14573/altex.2013.1.074 Food for thought… on evidence-based toxicology
ALTEX. 2009. PMID: 19565165 No abstract available.
Toward an evidence-based toxicology
Hoffmann S, Hartung T. Hum Exp Toxicol. 2006 Sep;25(9):497-513.
doi: 10.1191/0960327106het648oa.
Diagnosis: toxic!—Trying to apply approaches of clinical diagnostics and prevalence in toxicological considerations
Hoffmann S, Hartung T. Diagnosis: toxic!--trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations. Toxicol Sci. 2005 May;85(1):422-8. doi: 10.1093/toxsci/kfi099. Epub 2005 Feb 2. PMID: 15689419.
https://doi.org/10.1093/toxsci/kfi099