EBTC Research Contributions

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Camilla Svendsen; Paul Whaley; Gunn E Vist; Trine Husøy; Anna Beronius; Emma Di Consiglio et al. (2023): Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies. Available online at https://lens.org/163-149-060-517-551.

Paul Whaley; Stephen Wattam; Anna Mae Scott; John Vidler; The Evidence-Based Toxicology Collaboration (2023): A general-purpose protocol for facilitating standards compliance when planning systematic reviews. Available online at https://lens.org/143-343-960-246-439.


Geoff Frampton; Paul Whaley; Micah Bennett; Gary Bilotta; Jean-Lou C. M. Dorne; Jacqualyn Eales et al. (2022): Principles and framework for assessing the risk of bias for studies included in comparative quantitative environmental systematic reviews. In Environmental Evidence 11 (1). DOI: 10.1186/s13750-022-00264-0.

J M L Menon; F Struijs; P Whaley (2022): The methodological rigour of systematic reviews in environmental health. In Critical reviews in toxicology 52 (3), pp. 167–187. DOI: 10.1080/10408444.2022.2082917.

A Amina Wilkins; Paul Whaley; Amanda S Persad; Ingrid L Druwe; Janice S Lee; Michele M Taylor et al. (2022): Assessing author willingness to enter study information into structured data templates as part of the manuscript submission process: A pilot study. In Heliyon 8 (3), e09095‐e09095. DOI: 10.1016/j.heliyon.2022.e09095.

Aldert H Piersma; Nancy C Baker; George P Daston; Burkhard Flick; Michio Fujiwara; Thomas B Knudsen et al. (2022): Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity. In Current research in toxicology 3, p. 100074. DOI: 10.1016/j.crtox.2022.100074.

Daniel Krewski; Patrick Saunders-Hastings; Robert A Baan; Tara S Barton-Maclaren; Patience Browne; Weihsueh A Chiu et al. (2022): Development of an Evidence-Based Risk Assessment Framework. In ALTEX 39 (4), 667‐. DOI: 10.14573/altex.2004071

Paul Whaley; Nicolas Roth (2022): How we promote rigour in systematic reviews and evidence maps at Environment International. In Environment international 170, p. 107543. DOI: 10.1016/j.envint.2022.107543.

Paul Whaley; Thomas Piggott; Rebecca L Morgan; Sebastian Hoffmann; Katya Tsaioun; Lukas Schwingshackl et al. (2022): Biological plausibility in environmental health systematic reviews: a GRADE concept paper. In Environment international 162, p. 107109. DOI: 10.1016/j.envint.2022.107109.

Sebastian Hoffmann; Paul Whaley; Katya Tsaioun (2022): How evidence-based methodologies can help identify and reduce uncertainty in chemical risk assessment. In ALTEX 39 (2), 175‐. DOI: 10.14573/altex.2201131.

Sebastian Hoffmann; Elisa Aiassa; Michelle Angrish; Claire Beausoleil; Frederic Y Bois; Laura Ciccolallo et al. (2022): Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. In ALTEX 39 (3), 499–518‐. DOI: 10.14573/altex.2202141.


David Pamies; Marcel Leist; Sandra Coecke; Gerard Bowe; David G Allen; Gerhard Gstraunthaler et al. (2021): Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0). In ALTEX 39, 30‐. DOI: 10.14573/altex.2111011.

Hubert Dirven; Gunn Elisabeth Vist; Sricharan Bandhakavi; Jyotsna Mehta; Seneca E Fitch; Pandora Pound et al. (2021): Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. In Scientific reports 11 (1), p. 6403. DOI: 10.1038/s41598-021-85708-2.

Julia M.L. Menon; Judith van Luijk; Janne Swinkels; Eva Lukas; Merel Ritskes-Hoitinga; Nel Roeleveld et al. (2021): A health-based recommended occupational exposure limit for nitrous oxide using experimental animal data based on a systematic review and dose-response analysis. In Environmental research 201, p. 111575. DOI: 10.1016/j.envres.2021.111575.

Nawal Farhat; Katya Tsaioun; Patrick Saunders-Hastings; Rebecca L. Morgan; Siva Ramoju; Thomas Hartung; Daniel Krewski (2021): Systematic review in evidence-based risk assessment. In ALTEX 39 (3), 463–479‐. DOI: 10.14573/altex.2004111.

Paul Whaley; Bas J. Blaauboer; Jan Brozek; Elaine A. Cohen Hubal; Kaitlyn Hair; Sam Kacew et al. (2021): Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do. In ALTEX 38 (3), pp. 513–522. DOI: 10.14573/altex.2106111.

Sebastian Hoffmann; Bianca Marigliani; Sevcan Gül Akgün-Ölmez; Danielle Ireland; Rebecca Cruz; Francois Busquet et al. (2021): A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity. In Toxicological sciences : an official journal of the Society of Toxicology 183 (1), pp. 14–35. DOI: 10.1093/toxsci/kfab072.

Rob de Vries; Michelle M. Angrish; Patience Browne; Jan Brozek; Andrew A. Rooney; Daniele Wikoff et al. (2021): Applying evidence-based methods to the development and use of adverse outcome pathways. In ALTEX 38 (2), pp. 336–347. DOI: 10.14573/altex.2101211.


Cathalijn H. C. Leenaars; Katya Tsaioun; F.R. Stafleu; Kieron Rooney; Franck L. B. Meijboom; Merel Ritskes-Hoitinga; André Bleich (2020): Reviewing the animal literature: how to describe and choose between different types of literature reviews. In Laboratory animals 55 (2), pp. 129–141. DOI: 10.1177/0023677220968599.

Clemens Wittwehr; Paul Blomstedt; John Paul Gosling; Tomi Peltola; Barbara Raffael; Andrea-Nicole Richarz et al. (2020): Artificial Intelligence for chemical risk assessment. In Computational toxicology (Amsterdam, Netherlands) 13, p. 100114. DOI: 10.1016/j.comtox.2019.100114.

David Pamies; Marcel Leist; Sandra Coecke; Gerard Bowe; Dave Allen; Gerhard Gstraunthaler et al. (2020): Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0) - Draft for stakeholder discussion and call for action. In ALTEX 37 (3), pp. 490–492. DOI: 10.14573/altex.2007091.

Jan Brozek; Carlos Canelo-Aybar; Elie A. Akl; James M. Bowen; John R. Bucher; Weihsueh A. Chiu et al. (2020): GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence - An overview in the context of health decision-making. In Journal of clinical epidemiology 129, pp. 138–150. DOI: 10.1016/j.jclinepi.2020.09.018.

Paul Whaley; Elisa Aiassa; Claire Beausoleil; Anna Beronius; Gary Bilotta; Alan R. Boobis et al. (2020): Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER). In Environment international 143, 105926‐. DOI: 10.1016/j.envint.2020.105926.

Paul Whaley; Stephen W. Edwards; Andrew D. Kraft; Kate Nyhan; Andrew Shapiro; Sean Watford et al. (2020): Knowledge organization systems for systematic chemical assessments. In Environmental health perspectives 128 (12), 125001‐. DOI: 10.1289/ehp6994.

Taylor Wolffe; John Vidler; Crispin J. Halsall; Neil Hunt; Paul Whaley (2020): A Survey of Systematic Evidence Mapping Practice and the Case for Knowledge Graphs in Environmental Health and Toxicology. In Toxicological sciences : an official journal of the Society of Toxicology 175 (1), pp. 35–49. DOI: 10.1093/toxsci/kfaa025.


Taylor Wolffe; Paul Whaley; Crispin J. Halsall; Andrew A. Rooney; Vickie R. Walker (2019): Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management. In Environment international 130, p. 104871. DOI: 10.1016/j.envint.2019.05.065.

Martin L. Stephens; Sevcan Gül Akgün-Ölmez; Sebastian Hoffmann; Rob de Vries; Burkhard Flick; Thomas Hartung et al. (2019): Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test. In Toxicological sciences : an official journal of the Society of Toxicology 171 (1), pp. 56–68. DOI: 10.1093/toxsci/kfz128.

Judith van Luijk; Madalina Popa; Janne Swinkels; Julia M.L. Menon; Wynand Alkema; Nel Roeleveld et al. (2019): Establishing a health-based recommended occupational exposure limit for nitrous oxide using experimental animal data - A systematic review protocol. In Environmental research 178, p. 108711. DOI: 10.1016/j.envres.2019.108711.

Stevie van der Mierden; Katya Tsaioun; André Bleich; Cathalijn H. C. Leenaars (2019): Software tools for literature screening in systematic reviews in biomedical research. In ALTEX 36 (3), pp. 508–517. DOI: 10.14573/altex.1902131.


European Food Safety Authority; Evidence-Based Toxicology Collaboration (2018): Joint European Food Safety Authority and Evidence‐Based Toxicology Collaboration Colloquium Evidence integration in risk assessment: the science of combining apples and oranges 25–26 October 2017 Lisbon, Portugal. In EFSA Supporting Publications 15 (3). DOI: 10.2903/sp.efsa.2018.en-1396.

Kathy Archibald; Katya Tsaioun; J. Gerry Kenna; Pandora Pound (2018): Better science for safer medicines: the human imperative. In Journal of the Royal Society of Medicine 111 (12), pp. 433–438. DOI: 10.1177/0141076818812783.


Sebastian Hoffmann; Rob B. M. de Vries; Martin L. Stephens; Nancy B. Beck; Hubert Dirven; John R. Fowle et al. (2017): A primer on systematic reviews in toxicology. In Archives of toxicology 91 (7), pp. 2551–2575. DOI: 10.1007/s00204-017-1980-3.


Martin L. Stephens; Kellyn Betts; Nancy B. Beck; Vincent Cogliano; Kay Dickersin; Suzanne Fitzpatrick et al. (2016): The emergence of systematic review in toxicology. In Toxicological sciences : an official journal of the Society of Toxicology 152 (1), pp. 10–16. DOI: 10.1093/toxsci/kfw059.

Martin L. Stephens; Melvin E. Andersen; Richard A. Becker; Kellyn Betts; Kim Boekelheide; E. W. Carney et al. (2013): Evidence-based toxicology for the 21st century: opportunities and challenges. In ALTEX 30 (1), pp. 74–103. DOI: 10.14573/altex.2013.1.074.


Paul Whaley; Crispin J. Halsall; Marlene Ågerstrand; Elisa Aiassa; Diane Benford; Gary Bilotta et al. (2015): Implementing systematic review techniques in chemical risk assessment: Challenges, opportunities and recommendations. In Environment international 92, pp. 556–564. DOI: 10.1016/j.envint.2015.11.002.


Sebastian Hoffmann (2014): Evidence-Based Toxicology. In : Elsevier, pp. 565–567. Available online at https://lens.org/096-152-800-231-006.


von Aulock S (2013): Evidence-Based Toxicology Collaboration (EBTC). Editorial. In ALTEX 30 (1), p. 1. Available online at https://lens.org/143-210-701-843-985.


Sebastian Hoffmann; Martin L. Stephens; Thomas Hartung (2012): The evidence-based toxicology collaboration. In Toxicology Letters 211, S154‐. DOI: 10.1016/j.toxlet.2012.03.559.


Joanne Zurlo (2011): Evidence-based Toxicology Collaboration Kick-off Meeting. In ALTEX 28 (2). DOI: 10.14573/altex.2011.2.152.



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