EBTC Research Contributions

2025

Pavlovic, M.D. et al. (2025) Reporting quality of systematic review protocols in environmental and occupational toxicology: a meta-epidemiology study protocol. Evidence-Based Toxicology, 3(1). https://doi.org/10.1080/2833373x.2025.2480543

Jones, L.B. et al. (2025) Improving how we use workshops when solving complex research problems: reflections from the CHANGE project. Arch Toxicol. https://doi.org/10.1007/s00204-025-04062-8  

Sousa-Pinto, B. et al. (2025) Quantitative assessment of inconsistency in meta-analysis using decision thresholds with two new indices. Journal of clinical epidemiology, 181, p. 111725. https://doi.org/10.1016/j.jclinepi.2025.111725  

Senerth, E. et al. (2025) GRADE guidance 40: The GRADE evidence-to-decision framework for environmental and occupational health. Environment International, 197(109314), p. 109314. https://doi.org/10.1016/j.envint.2025.109314

2024

Hartung, T. and Tsaioun, K. (2024). Evidence-based approaches in toxicology: their origins, challenges, and future directions. Evidence-Based Toxicology, 2 (1). https://doi.org/10.1080/2833373x.2024.2421187

Senerth E, Tangri N, Krammer L, et al. (2024) Systematic review methods in environmental health: a critical interpretive synthesis to inform the evolution of systematic review guidance. Evidence-Based Toxicology 2(1). https://doi.org/10.1080/2833373X.2024.2443410  

Svendsen C, Mathisen GH, Vist GE, Husøy T, Ames HM, Beronius A, Di Consiglio E, Druwe I, Hartung T, Hoffmann S, et al. (2024). Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol. Evidence-Based Toxicology. 2(1). doi:10.1080/2833373x.2024.2371285. http://dx.doi.org/10.1080/2833373x.2024.2371285

Mathisen GH, Bearth A, Jones LB, Hoffmann S, Vist GE, Ames HM, Husøy T, Svendsen C, Tsaioun K, Ashikaga T, et al. (2024). Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. Arch Toxicol. 98(8):2299–2308. http://dx.doi.org/10.1007/s00204-024-03802-6

Whaley P, Blain RB, Draper D, Rooney AA, Walker VR, Wattam S, Wright R, Hooijmans CR. (2024) Identifying assessment criteria for in vitro studies: a method and item bank. Toxicol Sci. http://dx.doi.org/10.1093/toxsci/kfae083  

Mellor, D., Corker, K. S., & Whaley, P. (2024). Preregistration templates as a new addition to the evidence-based toxicology toolbox. Evidence-Based Toxicology, 2(1), 2314303. https://doi.org/10.1080/2833373X.2024.2314303

Vist, G. E., Ames, H. M. R., Mathisen, G. H., Husøy, T., Svendsen, C., Beronius, A., … Whaley, P. (2024). A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies. Evidence-Based Toxicology, 2(1). https://doi.org/10.1080/2833373X.2024.2418045

Haber, N. A., Errington, T. M., Daley, M., Whaley, P., & Nosek, B. A. (2024). Assessing the effects of a precommitment policy applied during peer review. Evidence-Based Toxicology, 2(1). https://doi.org/10.1080/2833373X.2024.2386955 


2023

Mathisen, G. H., Vist, G. E., Whaley, P., White, R. A., Husøy, T., Ames, H. M., Beronius, A., Di Consiglio, E., Druwe, I., Hartung, T., Hoffmann, S., Hooijmans, C. R., Machera, K., Prieto, P., Robinson, J. F., Roggen, E., Rooney, A. A., Roth, N., Spilioti, E., … Svendsen, C. (2023). Protocol: Testing the Performance of INVITES-IN, A Tool for Assessing the Internal Validity of In Vitro Studies. Evidence-Based Toxicology, 1(1), 2293289. https://doi.org/10.1080/2833373X.2023.2293289

Camilla Svendsen; Paul Whaley; Gunn E Vist; Trine Husøy; Anna Beronius; Emma Di Consiglio et al. (2023): Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies. Available online at https://lens.org/163-149-060-517-551.

Paul Whaley; Stephen Wattam; Anna Mae Scott; John Vidler; The Evidence-Based Toxicology Collaboration (2023): A general-purpose protocol for facilitating standards compliance when planning systematic reviews. Available online at https://lens.org/143-343-960-246-439.

EFSA Scientific Committee (SC); More S, Bampidis V, Benford D, Bragard C, Hernández-Jerez A, Bennekou SH, Koutsoumanis KP, Lambré C, Machera K, Mullins E, Nielsen SS, Schlatter J, Schrenk D, Turck D, Younes M, Kraft A, Naegeli H, Tsaioun K, Aiassa E, Arcella D, Barizzone F, Cushen M, Georgiadis M, Gervelmeyer A, Lanzoni A, Lenzi P, Lodi F, Martino L, Messens W, Ramos Bordajandi L, Rizzi V, Stancanelli G, Supej Š, Halldorsson TI. Guidance on protocol development for EFSA generic scientific assessments. EFSA J. 2023 Oct 30;21(10):e08312. doi: 10.2903/j.efsa.2023.8312. PMID: 37908452; PMCID: PMC10613941.

Struijs, F., Hooijmans, C. R., Buijs, M., Dahan, A., Hoffmann, S., Kiffen, R., Mandrioli, D., Menon, J., Ritskes-Hoitinga, M., Roeleveld, N., de Ruijter, A., Scheffer, G. J., Schlünssen, V., & Scheepers, P. T. J. (2023). Establishing a health-based recommended occupational exposure limit for isoflurane using experimental animal data: a systematic review protocol. Systematic Reviews, 12(1), 166. https://doi.org/10.1186/s13643-023-02331-0

2022

Geoff Frampton; Paul Whaley; Micah Bennett; Gary Bilotta; Jean-Lou C. M. Dorne; Jacqualyn Eales et al. (2022): Principles and framework for assessing the risk of bias for studies included in comparative quantitative environmental systematic reviews. In Environmental Evidence 11 (1). DOI: 10.1186/s13750-022-00264-0.

J M L Menon; F Struijs; P Whaley (2022): The methodological rigour of systematic reviews in environmental health. In Critical reviews in toxicology 52 (3), pp. 167–187. DOI: 10.1080/10408444.2022.2082917.

A Amina Wilkins; Paul Whaley; Amanda S Persad; Ingrid L Druwe; Janice S Lee; Michele M Taylor et al. (2022): Assessing author willingness to enter study information into structured data templates as part of the manuscript submission process: A pilot study. In Heliyon 8 (3), e09095‐e09095. DOI: 10.1016/j.heliyon.2022.e09095.

Aldert H Piersma; Nancy C Baker; George P Daston; Burkhard Flick; Michio Fujiwara; Thomas B Knudsen et al. (2022): Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity. In Current research in toxicology 3, p. 100074. DOI: 10.1016/j.crtox.2022.100074.

Daniel Krewski; Patrick Saunders-Hastings; Robert A Baan; Tara S Barton-Maclaren; Patience Browne; Weihsueh A Chiu et al. (2022): Development of an Evidence-Based Risk Assessment Framework. In ALTEX 39 (4), 667‐. DOI: 10.14573/altex.2004071

Paul Whaley; Nicolas Roth (2022): How we promote rigour in systematic reviews and evidence maps at Environment International. In Environment international 170, p. 107543. DOI: 10.1016/j.envint.2022.107543.

Paul Whaley; Thomas Piggott; Rebecca L Morgan; Sebastian Hoffmann; Katya Tsaioun; Lukas Schwingshackl et al. (2022): Biological plausibility in environmental health systematic reviews: a GRADE concept paper. In Environment international 162, p. 107109. DOI: 10.1016/j.envint.2022.107109.

Sebastian Hoffmann; Paul Whaley; Katya Tsaioun (2022): How evidence-based methodologies can help identify and reduce uncertainty in chemical risk assessment. In ALTEX 39 (2), 175‐. DOI: 10.14573/altex.2201131.

Sebastian Hoffmann; Elisa Aiassa; Michelle Angrish; Claire Beausoleil; Frederic Y Bois; Laura Ciccolallo et al. (2022): Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. In ALTEX 39 (3), 499–518‐. DOI: 10.14573/altex.2202141.

2021

David Pamies; Marcel Leist; Sandra Coecke; Gerard Bowe; David G Allen; Gerhard Gstraunthaler et al. (2021): Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0). In ALTEX 39, 30‐. DOI: 10.14573/altex.2111011.

Hubert Dirven; Gunn Elisabeth Vist; Sricharan Bandhakavi; Jyotsna Mehta; Seneca E Fitch; Pandora Pound et al. (2021): Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. In Scientific reports 11 (1), p. 6403. DOI: 10.1038/s41598-021-85708-2.

Julia M.L. Menon; Judith van Luijk; Janne Swinkels; Eva Lukas; Merel Ritskes-Hoitinga; Nel Roeleveld et al. (2021): A health-based recommended occupational exposure limit for nitrous oxide using experimental animal data based on a systematic review and dose-response analysis. In Environmental research 201, p. 111575. DOI: 10.1016/j.envres.2021.111575.

Nawal Farhat; Katya Tsaioun; Patrick Saunders-Hastings; Rebecca L. Morgan; Siva Ramoju; Thomas Hartung; Daniel Krewski (2021): Systematic review in evidence-based risk assessment. In ALTEX 39 (3), 463–479‐. DOI: 10.14573/altex.2004111.

Paul Whaley; Bas J. Blaauboer; Jan Brozek; Elaine A. Cohen Hubal; Kaitlyn Hair; Sam Kacew et al. (2021): Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do. In ALTEX 38 (3), pp. 513–522. DOI: 10.14573/altex.2106111.

Sebastian Hoffmann; Bianca Marigliani; Sevcan Gül Akgün-Ölmez; Danielle Ireland; Rebecca Cruz; Francois Busquet et al. (2021): A Systematic Review to Compare Chemical Hazard Predictions of the Zebrafish Embryotoxicity Test With Mammalian Prenatal Developmental Toxicity. In Toxicological sciences : an official journal of the Society of Toxicology 183 (1), pp. 14–35. DOI: 10.1093/toxsci/kfab072.

Rob de Vries; Michelle M. Angrish; Patience Browne; Jan Brozek; Andrew A. Rooney; Daniele Wikoff et al. (2021): Applying evidence-based methods to the development and use of adverse outcome pathways. In ALTEX 38 (2), pp. 336–347. DOI: 10.14573/altex.2101211.

2020

Cathalijn H. C. Leenaars; Katya Tsaioun; F.R. Stafleu; Kieron Rooney; Franck L. B. Meijboom; Merel Ritskes-Hoitinga; André Bleich (2020): Reviewing the animal literature: how to describe and choose between different types of literature reviews. In Laboratory animals 55 (2), pp. 129–141. DOI: 10.1177/0023677220968599.

Clemens Wittwehr; Paul Blomstedt; John Paul Gosling; Tomi Peltola; Barbara Raffael; Andrea-Nicole Richarz et al. (2020): Artificial Intelligence for chemical risk assessment. In Computational toxicology (Amsterdam, Netherlands) 13, p. 100114. DOI: 10.1016/j.comtox.2019.100114.

David Pamies; Marcel Leist; Sandra Coecke; Gerard Bowe; Dave Allen; Gerhard Gstraunthaler et al. (2020): Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0) - Draft for stakeholder discussion and call for action. In ALTEX 37 (3), pp. 490–492. DOI: 10.14573/altex.2007091.

Jan Brozek; Carlos Canelo-Aybar; Elie A. Akl; James M. Bowen; John R. Bucher; Weihsueh A. Chiu et al. (2020): GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence - An overview in the context of health decision-making. In Journal of clinical epidemiology 129, pp. 138–150. DOI: 10.1016/j.jclinepi.2020.09.018.

Paul Whaley; Elisa Aiassa; Claire Beausoleil; Anna Beronius; Gary Bilotta; Alan R. Boobis et al. (2020): Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER). In Environment international 143, 105926‐. DOI: 10.1016/j.envint.2020.105926.

Paul Whaley; Stephen W. Edwards; Andrew D. Kraft; Kate Nyhan; Andrew Shapiro; Sean Watford et al. (2020): Knowledge organization systems for systematic chemical assessments. In Environmental health perspectives 128 (12), 125001‐. DOI: 10.1289/ehp6994.

Taylor Wolffe; John Vidler; Crispin J. Halsall; Neil Hunt; Paul Whaley (2020): A Survey of Systematic Evidence Mapping Practice and the Case for Knowledge Graphs in Environmental Health and Toxicology. In Toxicological sciences : an official journal of the Society of Toxicology 175 (1), pp. 35–49. DOI: 10.1093/toxsci/kfaa025.

2019

Taylor Wolffe; Paul Whaley; Crispin J. Halsall; Andrew A. Rooney; Vickie R. Walker (2019): Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management. In Environment international 130, p. 104871. DOI: 10.1016/j.envint.2019.05.065.

Martin L. Stephens; Sevcan Gül Akgün-Ölmez; Sebastian Hoffmann; Rob de Vries; Burkhard Flick; Thomas Hartung et al. (2019): Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test. In Toxicological sciences : an official journal of the Society of Toxicology 171 (1), pp. 56–68. DOI: 10.1093/toxsci/kfz128.

Judith van Luijk; Madalina Popa; Janne Swinkels; Julia M.L. Menon; Wynand Alkema; Nel Roeleveld et al. (2019): Establishing a health-based recommended occupational exposure limit for nitrous oxide using experimental animal data - A systematic review protocol. In Environmental research 178, p. 108711. DOI: 10.1016/j.envres.2019.108711.

Stevie van der Mierden; Katya Tsaioun; André Bleich; Cathalijn H. C. Leenaars (2019): Software tools for literature screening in systematic reviews in biomedical research. In ALTEX 36 (3), pp. 508–517. DOI: 10.14573/altex.1902131.

2018

European Food Safety Authority; Evidence-Based Toxicology Collaboration (2018): Joint European Food Safety Authority and Evidence‐Based Toxicology Collaboration Colloquium Evidence integration in risk assessment: the science of combining apples and oranges 25–26 October 2017 Lisbon, Portugal. In EFSA Supporting Publications 15 (3). DOI: 10.2903/sp.efsa.2018.en-1396.

Kathy Archibald; Katya Tsaioun; J. Gerry Kenna; Pandora Pound (2018): Better science for safer medicines: the human imperative. In Journal of the Royal Society of Medicine 111 (12), pp. 433–438. DOI: 10.1177/0141076818812783.

2017

Sebastian Hoffmann; Rob B. M. de Vries; Martin L. Stephens; Nancy B. Beck; Hubert Dirven; John R. Fowle et al. (2017): A primer on systematic reviews in toxicology. In Archives of toxicology 91 (7), pp. 2551–2575. DOI: 10.1007/s00204-017-1980-3.

2016

Martin L. Stephens; Kellyn Betts; Nancy B. Beck; Vincent Cogliano; Kay Dickersin; Suzanne Fitzpatrick et al. (2016): The emergence of systematic review in toxicology. In Toxicological sciences : an official journal of the Society of Toxicology 152 (1), pp. 10–16. DOI: 10.1093/toxsci/kfw059.

Martin L. Stephens; Melvin E. Andersen; Richard A. Becker; Kellyn Betts; Kim Boekelheide; E. W. Carney et al. (2013): Evidence-based toxicology for the 21st century: opportunities and challenges. In ALTEX 30 (1), pp. 74–103. DOI: 10.14573/altex.2013.1.074.

2015

Paul Whaley; Crispin J. Halsall; Marlene Ågerstrand; Elisa Aiassa; Diane Benford; Gary Bilotta et al. (2015): Implementing systematic review techniques in chemical risk assessment: Challenges, opportunities and recommendations. In Environment international 92, pp. 556–564. DOI: 10.1016/j.envint.2015.11.002.

2014

Sebastian Hoffmann (2014): Evidence-Based Toxicology. In : Elsevier, pp. 565–567. Available online at https://lens.org/096-152-800-231-006.

2013

von Aulock S (2013): Evidence-Based Toxicology Collaboration (EBTC). Editorial. In ALTEX 30 (1), p. 1. Available online at https://lens.org/143-210-701-843-985.

2012

Sebastian Hoffmann; Martin L. Stephens; Thomas Hartung (2012): The evidence-based toxicology collaboration. In Toxicology Letters 211, S154‐. DOI: 10.1016/j.toxlet.2012.03.559.
 

2011

Joanne Zurlo (2011): Evidence-based Toxicology Collaboration Kick-off Meeting. In ALTEX 28 (2). DOI: 10.14573/altex.2011.2.152.