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Evidence-Based Toxicology Collaboration

Publications

Evidence integration in risk assessment: the science of combining apples and oranges

The European Food Safety Authority (EFSA) and the Evidence‐Based Toxicology Collaboration (EBTC) organised a Colloquium to develop a multistakeholder understanding of the best practices, challenges and research needs for evidence integration in CRA, with a focus on hazard identification and on combining multiple studies and end‐points for dose–response modelling. EFSA Supporting Publications, 2018


A primer on systematic reviews in toxicology

To provide the toxicology community with a starting point for conducting or understanding systematic reviews, we herein summarized available guidance documents from various fields of application. We have elaborated on the systematic review process by breaking it down into ten steps, starting with planning the project, framing the question, and writing and publishing the protocol, and concluding with interpretation and reporting. In addition, we have identified the specific methodological challenges of toxicological questions and have summarized how these can be addressed. Archives of Toxicology, 2017


The Emergence of Systematic Review in Toxicology

Here we address the state of systematic review methods in toxicology, historical antecedents in both medicine and toxicology, challenges to the translation of systematic review from medicine to toxicology, and thoughts on the way forward. We conclude with a recommendation that as various agencies and organizations adapt systematic review methods, they continue to work together to ensure that there is a harmonized process for how the basic elements of systematic review methods are applied in toxicology. Toxicological Sciences, 2016


Evidence-Based Toxicology

Regarding test assessment, in the search of solutions for various problems related to validation, such as the imperfectness of the reference standard or the challenge to comprehensively evaluate tests, the field of Diagnostic Test Assessment (DTA) was identified as a potential resource. DTA being an EBM discipline, test method assessment/validation therefore became one of the main drivers spurring the development of EBT.In the context of pathway-based toxicology, EBT approaches, given their objectivity, transparency and consistency, have been proposed to be used for carrying out a (retrospective) mechanistic validation. Advances in Experimental Medicine and Biology, 2016.


Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review

To aid those seeking to assess the methodological or reporting quality of studies relevant to toxicology, we conducted a scoping review of the available guidance with respect to four types of studies: in vivo and in vitro, (quantitative) structure-activity relationships ([Q]SARs), physico-chemical, and human observational studies. Our aims were to identify the available guidance in this diverse literature, briefly summarize each document, and distill the common elements of these documents for each study type. Environment International, 2016.


Evidence-Based Toxicology

Reference Module in Biomedical Sciences. Encyclopedia of Toxicology (Third Edition), 2014


Evidence-based toxicology for the 21st century: Opportunities and challenges

EBTC was recently established to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. At a EBTC workshop, presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathway-based testing methods consistent with the 2007 National Research Council report on "Toxicity Testing in the 21st Century", and adopting a governance structure and work processes to move that effort forward. Altex, 2013


Food for thought… on evidence-based toxicology 

"... It all began in 1993, when my friend Edmund Neugebauer co-edited the book Handbook of Mediators in Septic Shock. To the best of my knowledge, this was the first book to apply principles of evidence-based medicine (EBM) not only to clinical studies but also to animal studies and in vitro experimental work." Altex, 2009


Toward an evidence-based toxicology

The increasing demands on toxicology of large-scale risk assessment programmes for chemicals and emerging or expanding areas of chemical use suggest it is timely to review the toxicological toolbox. Like in clinical medicine, where an evidence-based medicine (EBM) is critically reviewing traditional approaches, toxicology has the opportunity to reshape and enlarge its methodology and approaches on the basis of compounded scientific knowledge. Such revision would have to be based on structured reviews of current practice, ie, assessment of test performance characteristics, mechanistic understanding, extended quality assurance, formal validation and the use of integrated testing strategies. Human & Experimental Toxicology, 2006


Diagnosis: toxic!—Trying to apply approaches of clinical diagnostics and prevalence in toxicological considerations

The assessment of relevance of toxicological testing was compared with approaches of diagnostic medicine, a discipline that faces a comparable situation. Considering the work of a toxicologist as setting a diagnosis for compounds, assessment tools for diagnostic tests were transferred to toxicological tests. In clinical diagnostics, test uncertainty is well accepted and incorporated in this assessment. Toxicological Sciences, 2005