Evidence-Based Toxicology Collaboration
EBTC believes that adopting principles of transparency, objectivity and consistency will allow regulators, industry and other stakeholders to make more informed decisions about the effects of chemicals on human health and the environment.
EBTC is conducting a systematic review to determine how well the Zebrafish Embryotoxicity Test (ZET) can predict developmental malformations in conventional guideline studies using rats and rabbits.
In vitro study designs are increasingly important in chemical risk assessment, but often poorly conducted and inadequately reported, and therefore difficult to make good use of in systematic reviews.
Evidence-based assessment of health risks posed by chemical substances involves the application of formalized approaches locating, assessing and synthesizing evidence in a manner which minimizes bias and maximizes the transparency and utility of results.
EBTC's Primer on Systematic Reviews in Toxicology summarizes current proposed approaches to adapting systematic review methods to chemical risk research, identifying commonalities and how remaining challenges could potentially be overcome.
EBTC was founded in 2011 at Johns Hopkins Bloomberg School of Public Health with the vision to make evidence-based methodologies the standard that is used to ensure public health, a healthy environment and a sustainable future.
EBTC is fulfilling this vision by bringing together the international toxicology community to work on adapting and developing evidence-based methods and frameworks that facilitate the use of evidence-based toxicology and systematic reviews to inform regulatory, environmental and public health decisions.
is the development and use of transparent, consistent, and objective methods for assessing scientific evidence to answer questions about adverse effects of chemical substances on living organisms.Learn More
What We Do
Current projects include a new critical appraisal tool and an investigation of the predictivity of a zebrafish assayLearn More
A list of our publications, including our "Primer" on evidence-based toxicology.Learn More
Staff, Board, and More
Learn about who works for us, our Board of Trustees, and our all-important Scientific Advisory Council.Learn More