The EBTC’s Zebrafish Work Group (ZWG) was formed to carry out a systematic review of the Zebrafish Embryotoxicity Test as a predictor of developmental toxicity in the standard international test for this outcome, namely, the Organization for Economic Cooperation and Development (OECD) test guideline 414 (TG414), “Prenatal Developmental Toxicity Study.” The ZWG is relying on the ongoing output of the EBTC’s Methods Work Group, which is addressing the methodological needs of the community of toxicologists who pioneer implementation of systematic review in toxicology.
The ZWG’s review is following the steps of a Cochrane Collaboration review of diagnostic test accuracy. The ZWG’s review will focus primarily on the performance of the Zebrafish Embryo Test in identifying whether or not chemicals are developmental toxicants, as compared with TG414 (performed in rats or rabbits), and secondarily address predictions of specific development effects such as mortality, gross organ malformations, and altered growth of the embryo.
The protocol for this systematic review is published and open for public comments.
The current members of the ZWG are:
- Sebastian Hoffmann (Project Leader, EBTC, Evidence-Based Toxicology, Systematic Reviews)
- Martin Stephens (EBTC Founding Director, Johns Hopkins Bloomberg School of Public Health, Evidence-Based Toxicology, Systematic Reviews)
- Katya Tsaioun (EBTC, Johns Hopkins Bloomberg School of Public Health, Evidence-Based Toxicology, Pharmacology and ADME)
- Francois Busquet (CAAT-Europe, Zebra Fish biology)
- Burkhard Flick (BASF, Toxicology)
- Sebastian Hoffmann (CAAT, Evidence-Based Toxicology, Systematic Reviews)
- Manoj Lalu (Ottawa Hospital Research Institute, Epidemiology)
- Alexandra Maertens (Post-Doctoral Fellow, Evidence-Based Toxicology, Johns Hopkins Bloomberg School of Public Health)
- Catherine Willett (Humane Society of the United States, Zebra Fish Biology and Tests Validation)
- Hilda Witters (Flemish Institute for Technological Research)
- Robert Wright (Johns Hopkins University, Informatics)
- Sevçan Gül Akgün (Marmara University Faculty of Pharmacy)
- Michalann Harthill (Ecologist, Retired)
- Bianca Marigliani (University of Sao Paolo)
- Cathalijn Leenars (Radboud Medical Center, Systematic Reviews)
- Thomas Hartung (CAAT, Toxicology)