Coursera Evidence-based Toxicology Course
World Pharma Week
June 20th, 2019, Seaport World Trade Center, Boston MA
EBTC's Katya Tsaioun spoke at the World Pharma Week in Boston on June 20 where she showed the data from EBTC modeling project on predicting drug liver toxicity using systematically reviewed published literature, public US EPA ToxCast database and adverse events databases. She highlighted the quality and detail of the data in published literature and other public and proprietary databases.
Free Public Workshop: Application of Evidence-based Methods to Construct Mechanistic Frameworks for the Development and Use of Non-animal Toxicity Tests
June 12, 2019, McMaster University, Hamilton, Ontario, Canada
EBTC/GRADE Working Group conducted a free public workshop entitled: “Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests.” The goal of this workshop was to bring together international regulatory bodies (US EPA, EFSA, OECD, NIEHS, risk assessors, academic scientists, and industry) to explore, via discussion of related themes, how systematic review methods and AOP concepts could be combined to develop and use non-animal test methods for predicting the toxicity of chemical substances in an evidence-based manner. The workshop preceded the annual GRADE meeting June 13-14 in Hamilton, ON.
The plenary talks at this workshop have been recorded and are now available to listen to here: https://youtu.be/NNa0r2qL4pI
Free Public Workshop on Integrating Mechanistic/In Vitro Evidence into the Risk Assessment
June 3-4, 2019, Washington, DC
The second National Academies free public workshop, Workshop on Integrating Mechanistic/In Vitro Evidence into the Risk Assessment. EBTC Director Katya Tsaioun is serving on the organizing committee of the US National Academies of Sciences series of workshops on integrating mechanistic/in vitro evidence into the risk assessment.
Assuring the Quality of Systematic Reviews Published in Toxicology and Environmental Health Journals
May 29-31, 2019, Research Triangle Park, North Carolina, USA
t4 (Transatlantic Think Tank for Toxicology) workshop for toxicology journal editors: “Assuring the Quality of Systematic Reviews Published in Toxicology and Environmental Health Journals.” This workshop brought together editors to develop a joint strategy to assure the quality of the systematic reviews that journals in the environmental health and toxicological sciences are publishing. This was an invitation-only event. Proceedings will be published in ALTEX. This workshop is funded by t4, the Transatlantic Think Tank for Toxicology, a collaboration of the toxicologically oriented chairs in Baltimore, Konstanz, and Utrecht sponsored by the Doerenkamp-Zbinden Foundation and the Evidence-based Toxicology Collaboration (EBTC) at Johns Hopkins University Bloomberg School of Public Health (USA).
Society of Toxicology 2019 annual meeting events:
- March 10: A Continuing Education session chaired by EBTC's Scientific Advisory Council vice-chair Daniele Wikoff. The session, "Conducting Systematic Review in Toxicology—Why, When, How?" introduces the SR concept and features talks by EBTC Board member Emily Sena, on assessment of study quality, and EBTC Research Fellow Paul Whaley on reporting and critically appraising SRs.
- March 13: EBTC's Katya Tsaioun will deliver a platform presentation on EBTC's work on off-target activity of troglitazone and rosiglitazone, analysed using evidence-based approaches in three evidence streams. This talk is part of the platform session “Safety assessment of pharmaceuticals in drug development.”
- March 13: Katya will then discuss the role of systematic literature review in retrospective analysis of existing data on the example of zebrafish embryotoxicity study in the session on the utility of in vitro developmental toxicity assays and building IATAs.
- CAAT and EBTC visiting scholar Dr. Sevcan Gül Akgün Olmez is presenting a poster on March13 on the results of the pilot study of EBTC’s systematic review of the zebrafish embryotoxicity test (poster board 3182).
- EBTC is conducting a Tox21 working group meeting on March 13 at 6 - 8 pm at the Renaissance Baltimore Harbor hotel (sponsored by Elsevier). Space is limited. Please see agenda and register here.
International Conference on Uncertainty in Risk Analysis
EFSA, the European Food Safety Authority, and the BfR, the German Federal Institute for Risk Assessment, co-organized an International Conference on Uncertainty in Risk Analysis in Berlin (Germany) on 20-22 February 2019. The EBTC Research Fellow Dr. Sebastian Hoffmann, gave a talk: ‘How evidence-based methodology can help reduce uncertainty in risk assessment’.
Theory and Practice of Systematic Review Webinars
EBTC has put together series of webinars produced by the Scientific Liaison Coalitionand sponsored by the Society for Risk Analysis on the theory and practice of Systematic Review. The program was chaired by The webinar on 11 September 2018was chaired by moderated by EBTC Board President Dr. John "Jack" R. Fowle III and featured introductions by its Director Dr. Katya Tsaioun and by Dr Kris Thayer ( US EPA IRIS Program) and Dr Elisa Aiassa (European Food Safety Authority). The second webinar was on November 27 had a talk by Dr. Kim Weaver from SYRCLE at the Radboud University Medical Center on "TAIL-ored: Applying the Concept and Methodology of SR and Meta-analysis to Preclinical Animal Studies" and a presentation by Dr. Daniele Wikoff from Tox Strategies on "Integration of Systematic Review to Support Development of Health-based Toxicity Values in Chemical Risk Assessments''. You may see the full program and download recordings here.
Protocols for EBTC Tox21 Project
EBTC published the protocols for the EBTC Tox21 project:
- Systematic review of animal and human randomized clinical trials
- Analysis of the US EPA ToxCast data
- Analysis of the Who Vigibase pharmacovigilance ("Real World Evidence") data
Workshops on Integrating Mechanistic / In Vitro Evidence into the Risk Assessment
EBTC Director Katya Tsaioun serves on the organizing committee of the US National Academies of Sciences series of workshops on integrating mechanistic / in vitro evidence into the risk assessment. The first workshop"Strategies and Tools for Conducting Systematic Reviews of Mechanistic Data to Support Chemical Assessments"was conducted on 10-11 December, 2018. You may listen to the talks and download the posters here.
EBTC Research Fellowship (August 2018)
EBTC has initiated a part-time Research Fellowship in collaboration with Lancaster University The post is being occupied by Paul Whaley, enabling his continued contributing to our work developing a critical appraisal tool for in vitro studies, and allowing Lancaster University and EBTC to collaborate in advancing our mutual interests in systematic mapping methods and the application of machine learning techniques to the automation of systematic reviews.
Evidence Integration Colloquium report published (May 2018)
We are pleased to inform you that the report on the EFSA/EBTC Colloquium on Evidence Integration in risk assessment is now published and is available here. EBTC is and EFSA are continuing the collaboration and are working on the topics for a possible 2019 joint Colloquium, continuing with the topic of evidence integration. If you are interested in getting involved, please contact us here.
Publishing standards in systematic review: Collaboration for Environmental Evidence Conference (April 2018)
Paris, France. EBTC Director Katya Tsaioun presented lessons learned from using systematic review in two projects aimed at comparing performance of the toxicology test methods and EBTC Research Fellow Paul Whaley discussed interventions which could improve the quality of systematic reviews published by environmental health and toxicology journals in two presentations at the second conference of the Collaboration for Environmental Evidence.
EBTC session at Society of Toxicology Annual Conference (March 2018)
San Antonio, Texas. EBTC's Daniele Wikoff has chaired an Informational Session at SOT 2018, titled "Moving beyond theory to the use of systematic review to support regulatory decision making for evidence-based risk assessment". The session featured Kristina Thayer (US EPA IRIS program), Elisa Aiassa (EFSA), Heather Reddick and Jessica Myers (Texas Commission on Environmental Quality), and Katya Tsaioun (EBTC), sharing their practical experience of using SR methodologies for risk assessment.
EBTC comments in support of IRIS program (February 2018)
EBTC submitted written comments to a public workshop organised by the NAS Committee to Review Advances Made to the IRIS Process. We emphasised the value and benefit to us from our collaboration with the new IRIS leadership at EPA (Kris Thayer, Director of the EPA IRIS program is a member of the EBTC Board of Trustees) and the EPA's role as a leader among US agencies in adopting the systematic review as part of chemical risk assessment, with such work being key to modernising risk assessment and building trust with all stakeholders
EBTC colleagues contribute to new GRADE guidance for interpreting strength of evidence from preclinical animal studies (February 2018)
Although the framework is primarily intended for the field of preclinical animal studies, it is also highly relevant for the field of toxicology, since the two fields share many issues including e.g. how to take into account how well the results from animals translate to humans. A number of researchers involved with EBTC, including Kris Thayer, Holger Schünemann, Emily Sena and Rob de Vries contributed to its development. (See here for the publication.)
Director of US EPA IRIS programme brings top-tier expertise to EBTC (December 2017)
EBTC is pleased to announce that Kristina Thayer, Ph.D. has joined our Board of Trustees. Dr Thayer serves as the Integrated Risk Information System (IRIS) Division Director, located within the US Environmental Protection Agency (EPA) National Center for Environmental Assessment (NCEA).
EBTC sponsors 4th International Symposium on Systematic Review and Meta-Analysis of Laboratory Animal Studies (ISSRMALAS) (September 2017)
This was another excellent conference in this series, with high-caliber speakers and EBTC staff presenting new research findings and sponsoring the poster session. Areas of particular interest in the EBT domain include the rise in interest in systematic mapping techniques as a precursor to systematic reviews, the growing importance of machine learning for dealing with the data volume problem in CRA.