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Evidence-Based Toxicology Collaboration


Society of Toxicology 2019 annual meeting events:

International Conference on Uncertainty in Risk Analysis

EFSA, the European Food Safety Authority, and the BfR, the German Federal Institute for Risk Assessment, are co-organising an International Conference on Uncertainty in Risk Analysis in Berlin (Germany) on 20-22 February 2019. The EBTC Research Fellow Dr. Sebastian Hoffmann, gave a talk: ‘How evidence-based methodology can help reduce uncertainty in risk assessment’.

Theory and Practice of Systematic Review Webinars

EBTC has put together series of webinars produced by the Scientific Liaison Coalitionand sponsored by the Society for Risk Analysis on the theory and practice of Systematic Review. The program was chaired by The webinar on 11 September 2018was chaired by moderated by EBTC Board President Dr. John "Jack" R. Fowle III and featured introductions by its Director Dr. Katya Tsaioun and by Dr Kris Thayer ( US EPA IRIS Program) and Dr Elisa Aiassa (European Food Safety Authority). The second webinar was on November 27 had a  talk by Dr. Kim Weaver from SYRCLE at the Radboud University Medical Center on "TAIL-ored: Applying the Concept and Methodology of SR and Meta-analysis to Preclinical Animal Studies" and a presentation by Dr. Daniele Wikoff from Tox Strategies on "Integration of Systematic Review to Support Development of Health-based Toxicity Values in Chemical Risk Assessments''. You may see the full program and download recordings here.

Protocols for EBTC Tox21 Project

EBTC published the protocols for the EBTC Tox21 project:

Workshops on Integrating Mechanistic / In Vitro Evidence into the Risk Assessment

EBTC Director Katya Tsaioun is serving on the organizing committee of the US National Academies of Sciences series of workshops on integrating mechanistic / in vitro evidence into the risk assessment. The first workshop"Strategies and Tools for Conducting Systematic Reviews of Mechanistic Data to Support Chemical Assessments"was conducted on 10-11 December, 2018. You may listen to the talks and download the posters here

EBTC Research Fellowship (August 2018)

EBTC has initiated a part-time Research Fellowship in collaboration with Lancaster University The post is being occupied by Paul Whaley, enabling his continued contributing to our work developing a critical appraisal tool for in vitro studies, and allowing Lancaster University and EBTC to collaborate in advancing our mutual interests in systematic mapping methods and the application of machine learning techniques to the automation of systematic reviews.

Evidence Integration Colloquium report published (May 2018)

We are pleased to inform you that the report on the EFSA/EBTC Colloquium on Evidence Integration in risk assessment is now published and is available here. EBTC is and EFSA are continuing the collaboration and are working on the topics for a possible 2019 joint Colloquium, continuing with the topic of evidence integration. If you are interested in getting involved, please contact us here.

Publishing standards in systematic review: Collaboration for Environmental Evidence Conference (April 2018)

Paris, France. EBTC Director Katya Tsaioun presented lessons learned from using systematic review in two projects aimed at comparing performance of the toxicology test methods and EBTC Research Fellow Paul Whaley discussed interventions which could improve the quality of systematic reviews published by environmental health and toxicology journals in two presentations at the second conference of the Collaboration for Environmental Evidence. 

EBTC session at Society of Toxicology Annual Conference (March 2018)

San Antonio, Texas. EBTC's Daniele Wikoff has chaired an Informational Session at SOT 2018, titled "Moving beyond theory to the use of systematic review to support regulatory decision making for evidence-based risk assessment". The session featured Kristina Thayer (US EPA IRIS program), Elisa Aiassa (EFSA), Heather Reddick and Jessica Myers (Texas Commission on Environmental Quality), and Katya Tsaioun (EBTC), sharing their practical experience of using SR methodologies for risk assessment.

EBTC comments in support of IRIS program (February 2018)

EBTC submitted written comments to a public workshop organised by the NAS Committee to Review Advances Made to the IRIS Process. We emphasised the value and benefit to us from our collaboration with the new IRIS leadership at EPA (Kris Thayer, Director of the EPA IRIS program is a member of the EBTC Board of Trustees) and the EPA's role as a leader among US agencies in adopting the systematic review as part of chemical risk assessment, with such work being key to modernising risk assessment and building trust with all stakeholders

EBTC colleagues contribute to new GRADE guidance for interpreting strength of evidence from preclinical animal studies (February 2018)

Although the framework is primarily intended for the field of preclinical animal studies, it is also highly relevant for the field of toxicology, since the two fields share many issues including e.g. how to take into account how well the results from animals translate to humans. A number of researchers involved with EBTC, including Kris Thayer, Holger Schünemann, Emily Sena and Rob de Vries contributed to its development. (See here for the publication.)

Director of US EPA IRIS programme brings top-tier expertise to EBTC (December 2017)

 EBTC is pleased to announce that Kristina Thayer, Ph.D. has joined our Board of Trustees. Dr Thayer serves as the Integrated Risk Information System (IRIS) Division Director, located within the US Environmental Protection Agency (EPA) National Center for Environmental Assessment (NCEA).

EBTC sponsors 4th International Symposium on Systematic Review and Meta-Analysis of Laboratory Animal Studies (ISSRMALAS) (September 2017)

 This was another excellent conference in this series, with high-caliber speakers and EBTC staff presenting new research findings and sponsoring the poster session. Areas of particular interest in the EBT domain include the rise in interest in systematic mapping techniques as a precursor to systematic reviews, the growing importance of machine learning for dealing with the data volume problem in CRA.