Programme

Programme of the First International Forum towards an Evidence-Based Toxicology (EBT)

Monday, 15th of October (Day 1)
16:00	Welcome
16:00	Welcome & get together
20:00	DINNER
Tuesday, 16th of October (Day 2)
09:00 – 9:15	Opening
	*The First International Forum Towards Evidence-Based Toxicology* THOMAS HARTUNG
9:15 – 10:00	SESSION 1	Current concepts and challenges
08:45 – 10:00	Introductory session: "Challenges of the current toxicological toolbox” SCIENTIFIC STEERING COMMITTEE
10:00 – 10:20	*“Current concepts and schemes of science-driven toxicological decision-making – an overview”* CHRIS PORTIER
10:20 – 10:30	Plenary discussion
10:30 – 11:00	COFFEE BREAK
11:00 – 12:15	SESSION 2	Evidence-based medicine (EBM)
11:00 – 12:00	*"Evidence-based Medicine & the Cochrane Collaboration. Purpose, tools, strengths, weaknesses, organisation"* EDMUND NEUGEBAUER, ROBERTA SCHERER
12:00 – 12:15	Plenary discussion
12:15 – 13:30	BUFFET LUNCH
13:30 – 14:30	SESSION 3	Comparing medicine and toxicology
13:30 – 14:10	*"How does toxicology relate to medicine - knowledge creation & decision making”* PHIL GUZELIAN, CLAUDIUS GRIESINGER
14:10 – 14:30	Plenary discussion
14:30 – 17:00	BREAKOUT GROUP SESSION 1	Taking stock. Definition/Declaration
	*(flexible coffee breaks)* “Taking stock of current information sources on hazard and risk (i.e. methods for generating new information as well as sources of existing information).” GROUP 1 (A and B): What is the process of science-based decision-making in toxicology today? GROUP 2 (A and B): Strength/weakness analysis of the current information sources and methods used in toxicolog GROUP 3 (A and B): How can we improve the toxicological toolbox? *“Working towards a definition and a declaration of EBT”* GROUP 4 (A and B): Working towards a definition of EBT GROUP 5 (A and B): Working towards a declaration of EBT
16:30 – 17:00	Consolidation of subgroups A and B of each group
17:00 – 17:50	Plenary session - Consolidated group results (10 minutes each)
17:50 – 18:20	Plenary discussion
18:20 – 18:30	Wrap up and closure of day 2
20:00	DINNER
Wednesday, 17th of October (Day 3)
09:00 – 10:25	SESSION 4	Uncertainty and risk analysis. Current concepts of EBT.
	*(20 min talk + 5 min discussion)*
09:00 – 09:25	*“Quantification of uncertainty within and between species and the role of uncertainty factors”* LUTZ EDLER
09:25 – 09:50	*“Aspects of test assessment”* SEBASTIAN HOFFMANN
09:50 – 10:15	*“Transparency in hazard and risk identification”* PHIL GUZELIAN
10:15 – 10:25	Plenary discussion
10:25 – 10:30	Short announcements: EBT section in Human and Experimental Toxicology PHIL GUZELIAN http://www.ebtox.org as a living platform of EBT AGNIESZKA KINSNER
10:30 – 11:00	COFFEE BREAK
11:00 – 13:15	SESSION 5	EBT: case studies and examples
	*(20 min talk + 5 min discussion)*
11:00 – 11:25	*“Arsenic exposure and type 2 diabetes: a systematic review combining experimental and epidemiological evidence”* ELLEN SILBERGELD
11:25 – 11:50	*“In vitro genotoxicity tests to detect carcinogenicity: systematic review”* LUTZ MÜLLER
11:50 – 12:15	*“Biological modelling as a method for data evaluation and integration in toxicology”* HUGH BARTON
12:15 – 12:40	*“A toxicogenomics and biology-based modelling framework for health risk assessment”* DENIS SARIGIANNIS
12:40 – 13:05	*“Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity - molecular mechanisms and lessons for pharmacotoxicity”* JÜRGEN BORLAK
13:05 – 13:15	Plenary discussion
13:15 – 14:30	BUFFET LUNCH
14:30 – 16:15	BREAKOUT GROUP SESSION 2	The way forward
	*(flexible coffee breaks)* “Examining the applicability of EBM tools to the processes of knowledge creation and decision-making in toxicology” GROUP 6 (A and B): Basic research GROUP 7 (A and B): Hazard identification GROUP 8 (A and B): Decision-making “Working towards a definition and a declaration of EBT – follow up” GROUP 4 (A and B): Working towards a definition of EBT – follow up GROUP 5 (A and B): Working towards a declaration – follow up GROUP 9 (A and B): Working towards a living movement of EBT
16:15 – 16:45	Consolidation of subgroups A and B of each group
16:45 – 17:45	Plenary session - Consolidated group rapporteurs report results (10 minutes each)
17:45 – 18:30	Plenary discussion
18:30	Closure of day 3 Rapporteurs: report writing
20:00	GALA DINNER
Thursday, 18th of October (Day 4)
9:00 – 15:00	SESSION 6	Wrapping up
09:00 – 10:00	Rapporteurs' presentation of their reports
10:00 - 10:45	Plenary discussion of the reports and results
10:45 – 11:15	COFFEE BREAK
11:15 - 12:45	Plenary session *“Implementing EBT - the next steps”* 1) Declaration, Definition 2) Work distribution: Meeting report, publication 3) Forming a living and continuing EBT movement 4) Financial issues, societies to endorse EBT
12:45 – 14:00	BUFFET LUNCH
14:00 - 14:45	Plenary session *“Is EBT prepared to meet the challenges of current and future toxicological decision-making process?"* SCIENTIFIC STEERING COMMITTEE
14:45 – 15:00	Wrap up THOMAS HARTUNG
15:00	Closure of the meeting