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Evidence-Based Toxicology Collaboration

SOT Satellite Meeting

Updates on 21st Century Toxicology Activities and Related Efforts:
Invited Presentations and Open Microphone
March 27, 2014
Phoenix, AZ

A representative of the Evidence-based Toxicology Collaboration (EBTC) summarized the EBTC’s recent activities at a meeting on “Updates on 21st Century Toxicology Activities and Related Efforts,” held on March 27, 2014 in Phoenix, Arizona, as a satellite meeting to the annual Society of Toxicology conference.  Martin Stephens, director of the EBTC’s North American activities, provided a review of evidence-based approaches and the growing interest of U.S. federal agencies and others in their application to toxicology. He then provided an introduction to the work of the EBTC, highlighting two activities. The first was the Collaboration’s ongoing systematic review of the performance of the Zebrafish Embryo Test as a predictor of developmental toxicity in mammals. The EBTC is finalizing the protocol for this review and is about to implement it, first as a pilot study and later as a definitive exercise. The primary aim of the review is to translate the framework of diagnostic test accuracy from evidence-based medicine to the assessment of test method performance in toxicology, via this case study. The second highlighted activity was the EBTC’s conceptual work on mechanistic validation as a means of establishing the relevance of 21st century toxicity testing methods to the biological pathways they have been designed to reflect. He referred meeting participants to the EBTC’s ‘Food for Thought’ article titled ‘Mechanistic Validation’ in ALTEX.

Other presentations at the SOT satellite meeting provided updates on 21st century toxicology-related activity at the National Institute for Environmental Health Sciences (Tox21), the Environmental Protection Agency (ToxCast), the Hamner Institutes for Health Sciences, the Johns Hopkins Center for Alternatives to Animal Testing or CAAT (the Human Toxome Project), and the Human Toxicology Project Consortium (HTPC), as well as an update on the SEURAT I program in Europe.  The meeting was organized by CAAT and the HTPC.