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Evidence-Based Toxicology Collaboration


Katya Tsaioun

Dr Katya Tsaioun, PhD. Director

Katherine (Katya) Tsaioun has extensive professional experience in developing and applying novel in vitro and in silico ADME and safety test methods in preclinical pharmaceutical programs, most recently at Safer Medicines Trust and previously at Apredica (now Evotec), taking the company to a position of leadership in non-animal safety assessment. Katya brings extensive experience of working collaboratively with technology companies, environmental and medical regulatory agencies, academics and non-profit organizations. Katya serves on a number of scientific review boards and study sections of the NIH and several disease foundations, co-edited ADMET for Medicinal Chemists (Wiley & Sons, 2011), earned her PhD from Tufts University in Human Nutrition Science in 1999 and completed her post-doctoral training at the Harvard Medical School.

Martin Stephens

Dr Martin Stephens, PhD. Founding Director

Martin L. Stephens is a senior research associate at the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), where he promotes new methods in toxicology and new approaches to assessing their performance.  Prior to joining Johns Hopkins University in 2011, Dr. Stephens was Vice-President for animal research issues at The Humane Society of the United States. He served on the National Academy of Sciences’ committee that produced the landmark report, Toxicity Testing in the 21st Century: A Vision and a Strategy. Martin has received the Society of Toxicology Enhancement of Animal Welfare Award, the Humane Society of the United States’ Russell and Burch Award, the Doerenkamp-Zbinden Award, and the CAAT Recognition Award for his contributions to alternative methods and animal protection. He received a PhD in biology from The University of Chicago

Sebastian Hoffmann

Dr Sebastian Hoffmann, PhD. Research Staff, European Affairs

Sebastian Hoffmann is a specialist in the validation and assessment of in vitro test methods, and the regulation of chemicals (REACH) and cosmetic ingredients. He has been supporting the EBTC secretariat since 2011. Previously, Sebastian has worked for the European Centre for the Validation of Alternative Methods (ECVAM) of the European Commission. His research activities focus on methodological challenges in the assessment of in vitro tests, the design and evaluation of integrated testing strategies, and the application of evidence-based approaches to toxicology. He is an appointed member of the European Commission’s Scientific Committee on Occupational Exposure Limits. Sebastian received his PhD from the University of Konstanz (Germany) in 2005 for his thesis Evidence-based In Vitro Toxicology.

Rob de Vries

Dr Rob de Vries, PhD, MA. Research Staff, Chair of the EBTC Scientific Advisory Council

Rob de Vries' research has always focused on the intersection between ethics and the methodological aspects of animal experiments, studying biology and philosophy and holding a PhD in the ethics of animal experimentation. He currently works as a scientific researcher and (project) manager at SYRCLE (the SYstematic Review Centre for Laboratory animal Experimentation) in Nijmegen, the Netherlands, where he is mainly responsible for organizing hands-on trainings in systematic reviews of non-clinical studies (notably for EFSA) and for coaching researchers who are conducting their own systematic reviews. He has been involved in several systematic reviews related to food safety, environmental safety, and harmful effects of medical interventions. Rob co-leads EBTC's development of new tools for improving the quality and consistency of peer-review of in vitro studies and is the current coordinator of Good Cell Culture Practice

Paul Whaley

Paul Whaley. Research Staff

Paul Whaley is an experienced advocate of the use systematic methods for reviewing evidence to support the development of environmental policy and regulation, working with a range of US and European regulators, industry, NGO and academic organisations to encourage uptake of improved evidence-based methodologies for chemical risk assessment. Paul is Associate Editor for Systematic Reviews at the journal Environment International (2017 IF 7.297), and is based at Lancaster Environment Centre in the UK. Paul is leading EBTC's work on systematic evidence surveillance methods and approaches to automation of systematic reviews, and is co-lead of EBTC's development of new tools for improving the quality and consistency of peer-review of in vitro studies.